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High concentrations and prolonged exposure to ROS causes extensive damage to various integral cellular biomolecules (Figure 1B), including proteins, lipids and nucleic acids, which ultimately hampers multiple cellular functions (25, 26, 49, 88)

The proportions of M1M6 and [ 3 H]BPC157 in plasma radioactive components at different sampling times demonstrated that [ 3 H]BPC157 was the main plasma component at 0.05 h (3 min) after administration and was subsequently degraded into small molecular peptide fragments in the following 0.167 h (10 min) (Figure 5A)

That said, combining injectable and topical approaches creates a two-pronged strategy that addresses skin from both the inside out and the outside in